Mouse Models of Cancer PDF ✓ Mouse Models ePUB

Mouse Models of Cancer PDF ✓ Mouse Models ePUB

Mouse Models of Cancer ❴PDF / Epub❵ ☉ Mouse Models of Cancer Auteur Cory Abate Shen – Larringtonlifecoaching.co.uk The laboratory mouse is an important model for addressing questions in cancer biology In recent years, the questions have becomerefined, and mouse models are increasingly being used to develop and tes The laboratory mouse is an important model for addressing questions in cancer biology In recent years, the questions have becomerefined, and mouse models are increasingly being used to develop and test cancer therapeutics Thus, the need forsophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them This laboratory manual provides cutting edge methods for generating and characterizing mouse models that accurately recapitulate many features Mouse Models ePUB å of human cancer The contributors describe strategies for producing genetic models, including transgenic germline models, gene knockouts and knockins, and conditional and inducible systems, as well as models derived using transposon based insertional mutagenesis, RNA interference, viral mediated gene delivery, and chemical carcinogens Tissue recombination, organ reconstitution, and transplantation methods to develop chimeric, allograft, and xenograft models are covered Approaches to characterize tumor development, progression, and metastasis in these models using state of the art imaging, histopathological, surgical, and other techniques are also included Other chapters cover the use of mouse models to test and optimize drugs in pre , co , and post clinical trials An appendix specifically addresses the use of mouse cancer models in translational studies and the integration of mouse and human clinical investigations This manual is therefore an indispensable laboratory resource for all researchers, from the graduate level upwards, who study cancer and its treatment.

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